The World Health Organization identifies headache disorders (“symptomatic at least once within the last year”) among the most common disorders of the nervous system, affecting 50% of adults worldwide.
Thirty percent of those affected reported having had a migraine in the last year. Moreover, 1.7 – 4% of adults worldwide experience headaches 15 or more days per month.
If on 8 of those 15 days, features of migraine headaches are also present, and if this persists for 3 months, then one would be diagnosed as having chronic migraines. Chronic migraines affect 1% of the population, or about 75,000,000 people across the globe.
It is estimated that about 36,000,000 Americans suffer from migraines, but only 1 in 3 people discuss this with a physician.
Depression and anxiety often accompany migraines, so suffering extends beyond physical pain.
The 2015 Global Burden of Disease study identified migraine as the third cause of disability in adults under the age of fifty. Migraines leave sufferers unable to function as usual, interfering with their physical and mental health, productivity, quality of life, and financial security.
Botox has even been found as efficacious in the treatment of migraines, and the FDA approves the use of Botox to treat migraines in adults who are age 18 and older.
Despite the number of effective treatments available, still some people experience refractory migraines, or migraines that do not respond to standard treatments and require specialty medication treatment.
Recent small studies (such as this one ) suggest the efficacy of ketamine infusion therapy in the treatment of chronic migraines. Ketamine is an antagonist of NMDA-subtype glutamate receptors, which are thought to play a role in pain transmission.
When facing a situation that few have done before, there are usually more questions than answers. Ketamine as a treatment for depression, especially TRD, is still in its infancy....